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Remember that anti-inflammatory effects, whilst potentially beneficial, are not the primary reason for prescribing these medications

Your provider may recommend temporarily pausing dose escalation, adjusting your maintenance dose, or exploring alternative GLP-1 formulations better suited to your gastrointestinal tolerance

consider temporarily stopping metformin and SGLT2 inhibitors (e.g., empagliflozin, dapagliflozin) if you're dehydrated, as advised by Diabetes UK Dietary modifications : Initially, avoid solid foods until vomiting subsides

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The main mechanisms include: Paternal deletion of the region (most common) Maternal uniparental disomy (UPD) both chromosome copies come from the mother Imprinting defects causing improper gene expression These genetic disruptions lead to abnormal development of the hypothalamus, affecting hunger, hormone regulation, and behavior