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However, toxins from poor diet, pollution, medications, stress, trauma, aging, infections, and radiation can deplete glutathione levels

J Gen Microbiol 137:637644

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While it decreases ROS generation by enhancing antioxidant enzyme activity, DPQ has also been associated with detrimental effects, including increased DNA damage and apoptosis in cardiomyocytes 170

16 This impermeability ensures rapid local regulation of NAD-dependent physiological processes and extensive compartmentalization of many enzymes involved in the biosynthesis or consumption of NAD + has also been described