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In addition, to determine the percentage distribution of reacted RT between GSH and protein thiols, we treated HeLa cells with RT and lysed the cells using trichloroacetic acid to separate proteins from small molecules (Fig
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These findings establish a pivotal link between -KG availability and disulfidptosis, suggesting that AMPK may prevent disulfide stress accumulation through NADPH homeostasis, a notion that requires further investigation
Heather Rogers told Insider
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