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Firstly, the synthesis of GSH-depleted multicomponent nanomedicines is so time-consuming that it still faces a huge technological gap from laboratory preparation to industrial production (Klochkov et al., 2021)
Defects in complex I are among the most common causes of mitochondrial diseases, contributing to disorders such as Leigh syndrome, mitochondrial encephalomyopathy and Parkinsons disease by disrupting ATP production and elevating oxidative stress 21,71,72,73
Additionally, it has been shown to enhance symptoms, improve physical fitness, and lower inflammation and body weight in patients with obesity and heart failure with preserved ejection fraction (Kosiborod et al., 2023)
Therapeutics Initiative
GLP-1 not only regulates blood glucose levels, but is also closely associated with various pathophysiological processes, such as inflammation
