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The faster you escalate, the more likely you are to hit a dose that causes dropout

171 Certain mutations of the methylenetetrahydrofolate reductase ( MTHFR ) gene are known to cause abnormal homocysteine metabolism, resulting in high homocysteine levels, and some studies have found these mutations may be more common in women with infertility

It depends on individual factors such as metabolism, overall health, and the severity of B12 deficiency

[4] GLP-1 receptor agonists most commonly cause nausea, vomiting, diarrhoea, and constipation, particularly during the dose escalation phase

Ive been thinking about how this data feeds into the bigger narratives playing out in GLP-1 and cardio-metabolic health spaces, which are wide and varied as youll see