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Accumulating evidence indicates that elevated levels of IR and circulating FFAsparticularly palmitatein T2DM contribute to -cell ERS through pathways including inositol-requiring enzyme 1 (IRE1)/X-box binding protein 1 (XBP1), protein kinase R-like endoplasmic reticulum kinase (PERK)/stimulates eukaryotic translation initiation factor 2 subunit- (eIF2), activating transcription factor-6 (ATF6), and thyroid adenoma associated gene (THADA) [70]
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Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM, et al
It is biologically plausible that its significant weight-reducing properties could lower inflammatory markers such as CRP and IL-6, but this has not been established in clinical trials
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It will also provide insights on how to adjust your routine to protect muscle as you lose fat
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