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Additionally, all cell cultures were maintained at 37C in a humidified incubator under a 5% CO 2 atmosphere

It has been investigated in research settings for its potential role in modulating inflammatory pathways and immune signaling mechanisms

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That bleeding advantage disappears when strong dual inhibitors of CYP3A4 and P-gp (ketoconazole, ritonavir, clarithromycin) are co-administered, as apixaban exposure can increase by up to 100% [1]

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