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Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]

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on the other hand, any non-invasive procedure, later on, would necessitate a laparoscopic management

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Their active pharmaceutical ingredients must come from FDA-registered manufacturers with Certificates of Analysis confirming purity, potency, and sterility