A follow-up extension study found that participants regained approximately two-thirds of lost weight within one year of stopping treatment, highlighting the importance of sustained therapy (Wilding et al., 2022, PMID: 35441470)
Sessions last longer and require more supplies and clinical monitoring
Li G, Wu R, Tong R, Bo B, Zhao Y, Gillen KM, et al
Consistently eating below roughly 600 to 800 net calories triggers metabolic adaptation mechanisms that reduce resting metabolic rate and accelerate lean mass breakdown
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