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Its practical advantage over earlier quinolinium analogues is permeability
The Sikiric group has consistently characterized BPC-157 as resistant to degradation in human gastric juice, a property attributed to its compact 15-residue length, its five proline residues (which disrupt protease recognition motifs), and the absence of cysteine-bridgedependent tertiary structure (Sikiric et al., 2018)
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It features a fatty diacid chain for ~6-day half-life, supporting weekly dosing
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