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Retrieved 7 March 2026
Visible changes in skin, muscle tone, or overall wellness tend to develop gradually over time
Understanding your personal predisposition to these changes before starting treatment allows you and your provider to set realistic expectations and develop a skin management plan
Injections are particularly appropriate for those with: Pernicious anaemia, an autoimmune condition affecting B12 absorption Conditions affecting the stomach or small intestine, such as Crohns disease or coeliac disease Those who have had gastric surgery or bariatric procedures Strict vegans and vegetarians not meeting their B12 needs through food or oral supplements For those who can absorb B12 normally, oral supplements are generally an effective and well-evidenced alternative to injections
Patients who were prescribed any study drug within one year preceding the index date or 30 days after the index date, were pregnant, received insulin, or were diagnosed with any cancer were also excluded
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