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This study supports that plan design decision.

Research Highlights: In a small, short-term, Phase 2 clinical trial in adults, a first-of-its-kind medication reduced triglyceride levels in most patients by more than 60%

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Furthermore, the abnormal aggregation of -syn to form LB interferes with cellular autophagy and protein degradation pathways, representing a significant indicator of neuronal degeneration and cell death (Meredith et al., 2002)