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Pregnant and breastfeeding individuals need careful dosing, as B12 supports fetal nervous system development
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Reintroducing miR-199a-3p in RCC cell lines inhibited proliferation and led to the arrest ofG1 phase by negatively regulating c-Met, thus suppressing HGF/c-Met axis and it's downstream signaling such as Akt, ERK1/2 and mTOR (Huang et al., 2014)
REDEFINE 1 and REDEFINE 2 are completed phase 3 trials published in NEJM with over 4,600 participants
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