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Hwang, J
LXA4 can decrease memory B-cell response via engagement of lipoxin A4 receptor (ALX)/formyl peptide receptor-2 (FPR-2) in synovial tissues of patients with RA, further enhancing the reduction of inflammation (167, 168)
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These signaling events are commonly assessed using enzyme activity assays, phosphorylation analysis, and gene expression profiling in laboratory systems
At the end of the experiment, RNA was extracted from the cells, and RT-qPCR analysis of gene expression was carried out using specific primers against rat fibroblast-specific protein-1 (FSP1), keratin-19 (KRT19), aggrecan, and type I and type II collagen
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