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Nutritional markers (B12, folate, vitamin D, ferritin): To identify any pre-existing deficiencies that may worsen with reduced appetite

Importantly, the combination of GIP and GLP-1 agonism produces synergistic rather than merely additive effects, with evidence suggesting enhanced central appetite regulation and improved peripheral metabolism compared to selective GLP-1 agonism alone (Coskun et al

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In methamphetamine models, blocking the action of VMAT2 decreases methamphetamine and cue-related reinstatement of active lever pressing [145]