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The FDA granted approval based on the clinically significant improvement in overall response rate (ORR) demonstrated in patients participating in study MK-6482-004 (NCT03401788) and later for advanced sporadic clear-cell RCC that has progressed through multiple treatments in 2023 (194)

Self-administration without professional guidance is strongly discouraged

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Data availability Raw data described in the manuscript will be made available upon request pending: References Jain, A