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Medical writing support, under the direction of the authors, was provided by Eric Comeau, Ph.D., of CMC Connect, McCann Health Medical Communications and was funded by Pfizer Inc., New York, NY, USA, in accordance with Good Publication Practice (GPP3) guidelines (Ann Intern Med 2015;163:461464).

GC-MS analysis After methanol was added, samples were shredded and subjected to sonication by adding an internal standard (C19 methylester)

Unfortunately, the study had numerous pitfalls, including protocol deviations during randomization and slow recruitment

The lowered tolerance maps onto altered absorption and slower metabolism