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10.3390/medicines6020068 210 WangG.HiramotoK.MaN.YoshikawaN.OhnishiS.MurataM.et al (2021a)

Patients often observe initial changes in the first weeks, but the more significant results emerge gradually over several months

We next investigated whether mitochondria are the source of ROS generation in RPE cells upon GSH depletion, we used MitoSOX Red to detect mitochondrial ROS (Fig