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While much research focuses on bariatric surgery patients, the mechanisms of B12 deficiency during rapid weight loss overlap significantly with GLP-1 therapy

Timelines reported below come from per-compound Phase 2/3 trials, the closest-analog REDEFINE 1 cagrilintide+semaglutide trial, and self-organized community protocols

Both of these injectable treatments can also be used by themselves, depending on the struggles that each patient is having with their weight loss process

They usually occur in the initial phase of starting the treatment or during dose escalation, but improve over time

While animal studies are encouraging, human data remain limited