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Age-dependent decrease of carnitine content in muscle of mice and humans

Some community reports mention localized injection-site warmth in animal models, though this is not systematically documented in peer-reviewed studies

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Moreover, oxidative damage to mitochondrial DNA (mtDNA) results in the release of mtDNA into the cytosol, where it triggers Toll-like receptor 9 (TLR9) and inflammasome activation, leading to further production of pro-inflammatory cytokines and recruitment of immune cells 67

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