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Alzheimers disease (AD), the most common form of dementia worldwide 270,271 , is characterized at the molecular level by the accumulation of A plaques, tau neurofibrillary tangles (NFTs), declined NAD + levels, mitochondrial stress, and impaired mitophagy, occurring first in the medial temporal lobe and eventually spreading to temporal and parietal cortices, and cortex 112,242,243,270,271,272
20%), TARDBP (45%), encoding TAR DNA-Binding Protein-43 (TDP-43), and Fused in Sarcoma ( FUS
Am J Physiology-Regulatory Integr Comp Physiol
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