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The infection in freshwater fish presents variation, including the species and size of fish, sources of areas, types of water, and seasons, which is determined by the interaction among environmental factors, liver fluke prevalence in definite hosts, distribution of first intermediate hosts, and biology and behavior of freshwater fish (104)

However, the small sample-size, the short treatment period, the absence of control groups, the lack of liver biopsy evaluation after treatment are just some of the limitations of these studies

This is where BPC-157 now sits

Thats why taking them together makes sense