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Our 2025 analysis identified early signs of reduced consumption among GLP-1 users

That matters because tolerability tracks the size of the swing during starts, dose jumps, missed doses and restarts, while at stable maintenance it tracks average concentration which splitting leaves unchanged by design

Efficacy was assessed before treatment and three months post-treatment

it may help raise the physiological threshold at which exertion triggers lactic acid buildup, potentially offering a crucial buffer against severe crashes and debilitating post-exertional malaise (PEM)