This slowing of digestion, while beneficial for weight loss, can also lead to nausea, especially during the initial phase of treatment
Inhibition of renal prostaglandin synthesis can lead to a variety of detrimental effects if kidney function is less than optimal, including fluid and electrolyte disorders, acute renal dysfunction, nephrotic syndrome, interstitial nephritis, and renal papillary necrosis
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the lever it exposes is frequency and cycle structure , not dose escalation