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Although SGLT2 inhibitors are proven to block the SREBP1c - ACC axis in metabolic tissues of animal models, we still need further proof to know if they directly affect tubular ferroptosis by regulating DNL in DKD (Kim et al., 2019)
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The lack of normalization of BDNF and NGF levels suggests that LipRSV did not engage plasticity-related pathways essential for behavioral rescue, reinforcing the notion that antioxidant strategies alone may be insufficient in ASD models
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