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ADA Perspective (Kome et al., 2025) Diabetes Care acknowledged microdosing semaglutide via multidose pens as "potentially useful" in specific clinical scenarios: Transitioning between GLP-1 medications Dose escalation or de-escalation Managing poor tolerability Reducing costs for cash-paying patients off-label, not endorsed by the manufacturer , and requires close monitoring
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A systematic literature review of observational studies
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Thurmond, Beckman Research Institute, City of Hope, United States Reviewed by Lei Jiang, City of Hope National Medical Center, United States
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