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Similar efficacy of DPP-4 inhibitors to either metformin or pioglitazone was also shown in formerly drug-nave patients who did not reach glycaemic goals with non-pharmacological interventions
Accessed 4/20/2015
The two approaches converge on a common endpoint, reducing the burden of cellular senescence, through complementary upstream mechanisms
The affected pathways clustered into several categories relevant beyond cosmetic applications: Extracellular matrix remodeling: Upregulation of decorin, multiple collagen types (I, III, VII), and matrix metalloproteinase inhibitors (TIMP-1, TIMP-2)
This may explain why various human protocols using different doses all report positive outcomes
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