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J Clin Endocrinol Metab 89:25832589 Thompson D, Edelsberg J, Colditz GA, Bird AP, Oster G (1999) Lifetime health and economic consequences of obesity

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In practice, I usually see better tolerance with half portions, softer preparation, and gradual increases

In the STEP 1 trial, once-weekly 2.4mg semaglutide produced a mean 14.9% body-weight reduction over 68 weeks establishing GLP-1 agonism as a leading anti-obesity mechanism

The data were analyzed at a significance level of less than 0.05 using SPSS version 20 (SPSS Inc., Chicago, IL, USA)