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This approach, focused on individual therapies that provide both glycemic control and cardio-renal protection, has demonstrated significant potential in mitigating the severe outcomes associated with diabetic kidney disease (DKD)

Precautions: As with all diabetes medications, individuals with history of pancreatitis should use linagliptin with caution, as there have been reports of pancreatitis associated with DPP -4 inhibitors [11]

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Hence the observed increase in GSH activity (total and reduced glutathione) in the magnesium treated diabetic animals may possibly be due to its effect on the enzymes gamma glutamyl transpeptidase (GGT), glutamate cysteine ligase and glutathione synthetase respectively

PMCID: PMC11863255