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124 A role for the gastroduodenal peptide CCK has also been suggested in the impaired motility of the gallbladder in people with diabetes, including reduced sensitivity of the gallbladder smooth muscle to plasma CCK and a reduction in CCK receptors in the gallbladder wall
Fortunately, many of these effects are temporary and tend to improve as the body adjusts to treatment
Gallup's Dan Witters calls that "a statistically meaningful decline that continues to inversely track with increased usage of GLP-1 medicine nationally." Meanwhile, the percentage of Americans who tell Gallup that they have been diagnosed with diabetes has leveled off since 2023 after 15 years of increases
The dose escalation is based on tolerability, not body mass
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