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Competing interests ML, FL, CR-D, AL, and RP are employees of, and are shareholders in, Sanofi
Sci Rep 2024
Common Side Effects (Both Oral and Injectable): Gastrointestinal Issues: These are the most common side effects for all GLP-1 medications: Nausea: Oral semaglutide (Rybelsus): 11-20% of patients Injectable semaglutide (Wegovy): 44% of patients Injectable tirzepatide (Zepbound): 30-37% of patients Why the difference: Lower bioavailability of oral medication means less systemic exposure, potentially resulting in fewer GI side effects
16 : 101106 Gecele M, Francesetti G, Meluzzi A
We believe that the increase in glucose metabolism occurs via up-regulation of glycolytic enzymes, since the observed metabolic effects were accompanied by significant upregulation in mRNA and protein expression of critical glycolytic genes (Fig
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