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Daily targets: Sodium: 2,000-2,500mg from food and supplementation Potassium: 4,000-4,700mg from food and conservative supplementation Magnesium glycinate: 300-400mg supplemental Calcium citrate: 600-1,000mg supplemental (divided doses) Vitamin D: 2,000 IU daily Implementation: Morning: magnesium glycinate (200mg) with food, electrolyte drink Midday: bone broth (400-500mg sodium), potassium-rich snack Afternoon: second electrolyte drink or salt tablet Evening: magnesium glycinate (200mg), calcium citrate (500mg), vitamin D Before bed: additional magnesium if experiencing cramps or insomnia This protocol is appropriate during dose escalation phases when side effects typically peak

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The tight negative feedback control that glutathione (GSH) exerts on the first of two enzymes responsible for glutathione synthesis, GCL, can explain this phenomenon