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Tirzepatide also causes burping through the same delayed gastric emptying mechanism

In the SURPASS-CVOT trial, tirzepatide met its primary endpoint of non-inferiority to dulaglutide for MACE-3, though it lacks an FDA-approved MACE-reduction indication in the U.S.[2] Post hoc cardiorenal analyses examined outcomes beyond the primary MACE endpoint in patients with concurrent cardiovascular and renal risk [3]

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By week six to eight, burping becomes occasional for the vast majority of patients, though some mild symptoms may persist

These medications may interact with diabetes treatments and may alter the absorption of some oral medicines because they slow stomach emptying