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The most frequently reported adverse events were gastrointestinal in nature, including nausea (occurring in 25-33% of patients), diarrhea, vomiting, constipation, and abdominal discomfort

Structural modifications extend its working window in research settings

GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP

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Future studies with larger sample sizes, randomized controlled designs, dose-response analyses, multivariate adjustments, and subgroup evaluations are essential to address these limitations