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Research published in the journal Diabetes, Obesity and Metabolism documented significant decreases in serum B12 levels in patients taking once-weekly semaglutide, alongside drops in zinc and albumin

They may also cause serious complications, including allergic reactions and infections

That is why it can be swallowed at all, and why it behaves like a small-molecule drug: real oral absorption, first-pass liver metabolism, a huge volume of distribution (39 L/kg in mice), and off-target enzyme binding

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