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When taking Semaglutide, you may experience some common side effects, including: Gastrointestinal Issues: Nausea, diarrhea, vomiting, constipation, and abdominal discomfort are frequent, especially when starting treatment or after a dose increase

PMC 4145307

I thought about asking the doctor or nurse next time I saw them for their logic (but in todays environment the standard answer from them is if you ask questions, they consider that aggressive behaviour, so Ive been rather put off speaking up)

Whoever could say (or sell) the wildest thing tended to draw the most attention

Mechanistically, its claimed effects track the biology of that TB4 motif: regulating actin dynamics, driving cell migration, and supporting new vessel growth and tissue repair