Dosing is individualised based on thyroid function tests (TSH, free T4) and clinical response
Regulatory status: Neither peptide is FDA-approved, and both are banned for competitive athletes by WADA
In women with cycle disorders or PCOS, ovulation may normalize again with weight reduction and improved insulin sensitivity
Specifically, Asp 21P forms a salt bridge with R242 ECL1 , while Trp 25P forms a hydrogen bond with D244 ECL1 and pi-pi stacking with W249 ECL1 , which was stabilized by Phe 22P
This becomes especially important when patients are not prioritizing: protein intake, resistance training, hydration, recovery, and sleep quality