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Animal models showing dramatic retinal preservation following peptide treatment may not replicate in humans due to species differences in receptor expression, metabolism, or disease pathology
Zlatar M, Kokot A, Vuletic LB, Masnec S, Kralj T, Perisa MM, et al
Y.VeraartJ
Moreover, the metabolite markers associated with responders and non-responders to metformin are not clearly established as either a cause or an effect of genetic alterations on the pharmacokinetics of metformin (Florez, 2017)
A principled approach is to introduce compounds one at a time, establish a baseline, and observe carefully before adding another
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