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Furthermore, IL-1, TNF-, and complement component subunit 1q (C1q) encourage the transformation of astrocytes into reactive astrocytes (A1), subsequently impairing the astrocytic capacity to regulate microglial activity [132]
However, these bumps have bigger openings on the dermis which allow oxygen to enter and oxidize melanin resulting in the black hue
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These quinones combine with DNA to form structures that link with deoxy purine components, and this results in instability in the genome
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