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To determine whether Trim37 -deletion-induced PGC depletion is germ cell autonomous, we first constructed a Trim37 knockout embryonic stem cell line ( Trim37 -del) based on an E14-derived ESC line in which 3Flag was knocked in at the C-terminus of Trim37 ( Trim37-3 Flag ) (Supplementary information, Fig
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Shifts in microbial populations such as increased Prevotella and decreased Turicibacter along with disturbances in bile acid metabolism and lipid homeostasis, collectively highlight the gutliver axis as a central mechanism in cadmium-induced hepatotoxicity (4)
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