While density for the N-terminal lipidation was not visible in the lower resolution cryo-EM map of the repeat Cagri-CTR-Gs complex ( N = 2), the outward rotamer of H296 ECL2 was observed, congruent with similar interactions between the N-terminal acylation and ECL2
Subsequent experiments confirmed that KRAS mutations induce resistance to MET-targeted therapies [151]
Author contributions ZH: Conceptualization, Methodology, Software, Validation, Visualization, Writing original draft, Writing review and editing
They target different receptors (two versus three), have different pharmacokinetics, and produce different metabolic effects per milligram
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