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GLP-1 drugs already carry a significant GI side-effect burden, and adding a supplement that independently irritates the stomach or alters motility can compound the problem

In addition to water and electrolyte balance, the kidneys regulate acid-base balance, regulate arterial pressures, control body fluid osmolarity, and allow for excretion of metabolic waste products and xenobiotic substances

It contributes to cardiac functional and structural well-being

It simply means these substances have been moved out of the significant safety risks category and are now awaiting formal evaluation by the Pharmacy Compounding Advisory Committee (PCAC)