However, its potency also means long-term use can lead to desensitization if not cycled properly
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34 Angarita et al 15 found that pretreatment with a clinically relevant (antidiabetic) dose of exenatide (5 g, 0.02 mL) did not alter the cocaine-related behaviors or subjective effects such as euphoria and wanting cocaine in people with cocaine use disorder compared to placebo (saline 0.02 mL)
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While most people tolerate GLP-1 medications like semaglutide or tirzepatide very well, it's important to recognize when GLP-1 symptoms go beyond normal adjustment