Neither type of evidence should be treated as interchangeable with human clinical evidence
How to Manage Constipation on GLP-1 Medications Constipation is a common side effect when taking GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), or tirzepatide (Mounjaro)
While that number may not seem as significant as other figures, consider that 5% weight loss or more has also been associated with health improvements in metabolic function, including fat loss in the abdomen and liver and insulin sensitivity
The incretin effect is a key physiological principle where oral glucose stimulates a much larger insulin response than intravenous glucose
All doses of once-weekly tirzepatide (5 mg, 10 mg, and 15 mg) were superior or non-inferior to insulin