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If you have impaired kidney function, some research suggests these high doses may cause further deterioration, so consult with your doctor before supplementing
What they often do not offer is clinical oversight, personalized formulation, or integration of IV therapy into an active treatment plan
doi:10.1056/NEJMoa1600869 Scheen AJ, Paquot N
Chronic conditions (tendonitis, joint issues): Typically requires 48 weeks of consistent use to see substantial improvements, with continued benefits over 12+ weeks
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