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A key conceptual priority for the field will be to distinguish direct signal transmission from the propagation of ferroptosis susceptibility states, as these processes may reflect fundamentally different modes of tissue-level coordination

Much of the foundational research also comes from a single research group, which limits the breadth of independent validation

Nutritional reset of oxidative stress (OxS) Virus-induced OxS with excess levels of ROS i.e., superoxide anion (O 2 - ), hydroxyl radical ( OH), singlet oxygen ( 1 O 2 ), and hydrogen peroxide (H 2 O 2 ), could trigger severe clinical manifestations including hyper-inflammation, tissue damage, thrombosis, and MODS in COVID-19, which may continue in PASC 553,554

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