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2026 Europe PMC Retatrutide in type 2 diabetes mellitus and obesity: an overview

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In the vascular system, oxidative stress in diabetes activates ROS-mediated Akt and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascades, promoting autophagy in endothelial cells while downregulating HDAC6 expression, which impairs cell migration and adhesion

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Cell viability is presented as [%] of viability of non-treated cells, which is considered to be equal to 100%

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