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Derm Pract Concept
Anti-Inflammatory Effects: B12 reduces interleukin-6 (IL-6) levels by 25-30% and tumor necrosis factor-alpha (TNF-) by 20%, per a 2025 JAMA Neurology randomized controlled trial (n=1,500)
Microglia respond rapidly to hyperactive neurons and wrap their processes around axons to facilitate rapid repolarization, thus preventing excitotoxicity and maintaining neuronal viability in mice (Kato et al., 2016)
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If nausea is severe enough to prevent adequate nutrition, reduce both compounds to the last tolerated dose and extend the stabilization period before attempting re-escalation
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