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Individuals who are severely immunocompromised, including those with HIV/AIDS with low CD4 counts, patients receiving chemotherapy, or those taking high-dose immunosuppressive medications, should consult their specialist before using probiotics due to rare reports of systemic infections caused by probiotic organisms

Increased oxidative stress and decreased antioxidant defense responses have been reported in HIV-positive patients 121

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That difference shapes everything from efficacy data to side-effect profiles

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