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SUMOylation is a small ubiquitin-like modifier (SUMO) connected to the substrate protein through a tertiary enzymatic reaction ( 2 O 2 group in the phospholipid fatty acid chain, resulting in the inhibition of lipid peroxidation of the cell membrane in silico ( Since GPX4 is a core regulator of ferroptosis, although it is unknown whether the phosphorylation, glycosylation or SUMOylation of GPX4 affect ferroptosis, it would be of interest to investigate it in future translational studies

Senescent cells accumulate over time and are characterized by altered gene expression, resistance to apoptosis, and secretion of inflammatory mediators collectively referred to as the senescence-associated secretory phenotype (SASP)

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